Coagulation procofactor activation by factor XIa
نویسندگان
چکیده
منابع مشابه
The effect of platelets in the activation of human blood coagulation factor IX by factor XIa.
We report here the effect of activated human platelets on the activation of human factor IX by human factor XIa. Factor IXa formed during activation was determined via its ability to activate bovine factor X. To increase sensitivity, phospholipids and bovine factor VIIIa were present in the assay. The kinetic parameters of the factor IX activation were determined in the presence of 10 mmol/L Ca...
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Activation of precursor proteins by specific and limited proteolysis is a hallmark of the hemostatic process. The homologous coagulation factors (F)V and FVIII circulate in an inactive, quiescent state in blood. In this so-called procofactor state, these proteins have little, if any procoagulant activity and do not participate to any significant degree in their respective macromolecular enzymat...
متن کاملThe mechanism by which heparin promotes the inhibition of coagulation factor XIa by protease nexin-2.
Previous kinetic studies have shown that protease nexin-2 is a potent, reversible, and competitive inhibitor of factor XIa. Here we show that high molecular weight heparin potentiates the ability of protease nexin-2 to inhibit factor XIa with a parabolic concentration dependence, predominantly because of an increase of the association rate constant with little perturbation of the dissociation r...
متن کاملSynergy Between Tissue Factor and Exogenous Factor XIa in Initiating Coagulation.
OBJECTIVE Recent evidence suggests involvement of coagulation factor XIa (FXIa) in thrombotic event development. This study was conducted to explore possible synergies between tissue factor (TF) and exogenous FXIa (E-FXIa) in thrombin generation. APPROACH AND RESULTS In thrombin generation assays, for increasing concentrations of E-FXIa with low, but not with high TF concentrations, peak thro...
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Coagulation factor VIIa (FVIIa) is present at subnanomolar concentration and represents a small percentage of the total amount of FVII in the circulation. FVIIa is poised to initiate blood clotting when it encounters its pivotal cofactor tissue factor (TF) which becomes exposed to blood upon vascular rupture. The requirement for complex formation with TF in order for FVIIa to express procoagula...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2010
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7836.2010.03899.x